Signalment:5-year-old, female spayed, Golden/ Labrador mix canine
History:The patient presented to the referring veterinarian for an onset of seizures in February 2021. Owner also reported reverse sneezing for years. The neurological and physical exam were both within normal limits. An MRI revealed an oval shaped mass in the right olfactory bulb/frontal lobe that was strongly contrast enhancing with significant perilesional edema. The cribriform plate was noted to be intact. Options of medical management, radiation therapy and surgical debulking were discussed and the owner elected for surgical debulking (transfrontal craniotomy) and radiation therapy. Two separate surgeries were required to resect the majority of the tumor. Differentials of a meningioma vs. carcinoma were discussed and biopsy revealed a carcinoma. The animal was treated with 20 fractions of Intensity-modulated radiation therapy (IMR) and continued to have several cluster seizures approximately every 7 weeks requiring extensive hospitalization. A repeat MRI was done in July 2021, revealing an irregular contrast enhancing mass in the region of the cribriform plate along with multiple other new masses around the cerebral cortex. The following week the animal was euthanized.
Gross Lesions:Nasal cavities and brain: Nasal adenocarcinoma with cribriform invasion and meningeal metastases