Example Synoptic Report – anal sac adenocarcinoma Please enable JavaScript in your browser to complete this form.Please enable JavaScript in your browser to complete this form.This report generator has not been peer reviewed - if used for diagnostic purposes, pathologists should review the information and use at their own risk.SignalmentRelevant Clinical HistorySamples SubmittedLeft anal sacRight anal sacInternal iliac lymph nodeUnspecified lymph nodeOther lymph node (specify)Other lymph nodeSample Measurements (cm)Tumor Measurements (cm)Gross DescriptionSample inked?Yes, by submitterYes, by laboratoryNo (representative sections)Histologic subtypeSolid subtypeOther subtype with < 50% solid componentOther subtype lacking solid componentNeoplasia at Margin?PresentAbsentHistologic Tumor Free Distance - deep (mm)Histologic Tumor Free Distance - peripheral (mm)Tissue BarriersCapsuleOtherOther Tissue Barrier(s)Peripheral InfiltrationNone1 focus of infiltration2 or more foci of infiltrationPeripheral infiltration is defined as neoplastic aggregates found separated from the main nodule within the peripheral connective tissue and/or muscle. From: Pradel et al. 2018Tissues InfiltratedPeripheral connective tissuePerirectal musculatureOtherOther Tissue(s) InfiltratedLymphovascular InvasionNot identifiedEquivocalPresentLymphovascular Invasion Criteria DetectedThrombus adherent to intravascular tumorTumor cells invading through a vessel wall and endotheliumNeoplastic cells within a space lined by lymphatic or blood vascular endotheliumNeoplastic cells in a structure confirmed to be a lymphatic or blood vessel by the use of IHC markersNecrosisNonePresentEstimated % NecrosisMitotic Count per 2.37mm2PleomorphismLow - Less than 25% of cells with anisocytosis and/or anisokaryosisModerate - 25 - 75% of cells with anisocytosis and/or anisokaryosisMarked - Greater than 75% of cells with anisocyosis or anisokaryosisPer Skorupski et al. 2018Nuclear PleomorphismLow - Less than 5% of cells with nuclei 2x larger than adjacent cellsModerate - 5-10% of cells with 2x larger nucleiMarked - More than 10% of cells with 2x larger nucleiPer Pradel et al. 2018Lymph Node MetastasisNoYesLymph Nodes SubmittedLymph Nodes With MetastasisOrgan MetastasisNot evaluatedNot detectedPresentOrgans With MetastasisE-cadherin ExpressionLess than 75%75% or moreSee Polton et al. 2007 and Skorupski et al. 2018Microscopic DescriptionMorphologic DiagnosisCommentsSubmit
