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Canine, 3-year-old, mixed breed, female. Ehlers–Danlos syndrome (EDS-like), dermatosparaxis or cutaneous asthenia is a genetically and biochemically diverse disorder that encompasses multiple heritable, congenital defects of dermal connective tissue. There is a continuum of clinical severity from mild to severe. Hyperextensibility and decreased tensile strength of the skin are the unifying clinical features. Affected dogs has skin extensibility index greater than 14.5% (formula: EI=vertical height of skin fold/body lenghth) X 100. Histologically, abnormal collagen fibers are characterized by shortening, disarray, curling, uneven size and width and diffuse thin and wispy fibers. Affected collagen fibers demonstrate red cores, in contrast to the diffuse blue staining of normal collagen on Masson’s trichrome stain. Reference 1. Gross TL et al. Skin Diseases of the Dog And Car Clinical and Histopathologic Diagnosis. 2005. Contributors: Drs. Fabrizio Grandi and Fábio Médici
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